Stockton III DD-646 - Information

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Stockton III DD-646

Stockton III(DD-646: dp. 1,630; 1. 348'3; b. 36'1; dr. 17'6, s. 37.4 k.; cpl. 276; a. 4 5, 4 40mm., 7 20mm., 5 21" tt., 2 act., 6 dcp.; cl. Gleaves)The third Stockton (DD-646) was laid down on 24 July 1942 at Kearny, N.J., by the Federal Shipbuilding and Drydock Co.; launched on 11 November 1942; sponsored by Mrs. Horace K. Corbin; and commissioned on 11 January 1943, Lt. Comdr. R. E. Braddy in command.After shakedown, Stockton joined the Atlantic Fleet on 15 March 1943 and began escorting convoys between New York and North African ports. Between 28 May 1943 and 3 January 1944, she escorted four convoys. On 24 January 1944, she got underway for the South Pacific.On arrival, Stockton joined the 7th Fleet forces assembled for the invasion of Los Negros Island in the Admiralties. She participated in the initial bombardment that cleared the way for the landings on 29 February and remained in the area for three days, patrolling and giving fire support to the forces ashore. From 9 to 13 March, she supported similar but smaller landings in Seeadler Harbor. As American forces leapfrogged along the northern coast of New Guinea, Stockton acted as an antiaircraft and antisubmarine screening vessel during the landings in Humboldt Bay on 22 April and at Wakde on 17 May; and she provided gunfire support for the Biak landings on 27 May. While off Biak, she received minor damage when hit by a shell from a shore battery on 28 May, and on 12 June, she towed Kalk (DD-611) into Humboldt Bay, after that destroyer had been immobilized by a bomb hit amidships.On 2 July, she was with the invasion forces off Noemfoor and acted both as screening and fire-support ship during the landings. After a month of escort and training duty along the northern coast of New Guinea, she sailed from New Guinea on 22 August to join units of the 3d Fleet for the invasion of the Palau Islands. The destroyer escorted the transports as they approached Peleliu on 15 September and protectedthem after the landings until she headed home on l0 October.After overhaul at Seattle, Wash., Stockton completed refresher training at Pearl Harbor on 24 January 1945. Between 10 February and 9 March, she screened escort carriers as they provided air cover for the landings on Iwo Jima. On 21 February, two days after the landings, Stockton's group was attacked by four suicide planes, which sank the escort carrier Bismarck Sea (CVE-95), and damaged Lunga Point (CVE-94). From 18 March to the end of the war, the destroyer escorted replenishment units of the Logistics Support Group as they provided fuel and supplies to the fleet during the Okinawa campaign and the concurrent air strikes on the Ryukyus and the Japanese home islands. On 31 March-the day before the Okinawa landings— Stockton and Morrison (DD-560) sank the Japanese submarine, 1-8, after a three and one-half hour action. In early April, Stockton directed the salvage of Thornton (AVD-11), which had collided with two tankers of Stockton's group.Stockton continued her support duties during the first month and one-half of the occupation of Japan. She sailed on 15 October from Japan and proceeded, via Singapore and Capetown, to New York. The destroyer was decommissioned on 16 May 1946 and placed in reserve at Charleston, S.C. She was struck from the Navy list on 1 July 1971.Stockton received 8 battle stars for her World War II service.

General election for Tennessee House of Representatives District 97

John Gillespie defeated Gabby Salinas in the general election for Tennessee House of Representatives District 97 on November 3, 2020.

There were no incumbents in this race. The results have been certified. Source

Democratic primary for Tennessee House of Representatives District 97

Gabby Salinas defeated Ruby Powell-Dennis, Allan Creasy, and Clifford Stockton III in the Democratic primary for Tennessee House of Representatives District 97 on August 6, 2020.

There were no incumbents in this race. The results have been certified. Source

Republican primary for Tennessee House of Representatives District 97

John Gillespie defeated Brandon Weise in the Republican primary for Tennessee House of Representatives District 97 on August 6, 2020.

There were no incumbents in this race. The results have been certified. Source

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After shakedown off San Diego, California, Morrison departed Seattle 25 February 1944 for the South Pacific, via Pearl Harbor and the Marshalls. In mid-April the destroyer joined TG 50.17 for screening operations off Seeadler Harbor, Manus, Admiralties, during the fueling of carriers then striking Japanese installations in the Carolines.

Morrison returned to Pearl Harbor 9 May to train for the giant amphibious leap into the Marianas. Departing Pearl 31 May via Roi, Marshalls, she arrived east of Saipan 13 June for a busy month. Her accurate gunfire supported the initial landings the 15th and provided close fire support thereafter. With little aid the crew fought off night air attacks 17 through 19 June. Of 40 enemy planes that approached at dusk the 17th, only 15 got by the attacks of the Navy&rsquos carrier interceptor planes and Morrison shot down three of those.

On 2 August the destroyer rendezvoused off Guam with TG 58.4 for flight operations following the landings 21 July. Eight days later Morrison departed Guam for Eniwetok, Marshalls, where she remained from the 13th until she got underway 29 August for the Philippines, arriving off Mindanao the morning of 9 September. That same day, the beginning of a 2-day strike on Mindanao, a Japanese convoy of 50 sampans and freighters was sighted heading north. Morrison led the intercepting force which destroyed the 10 to 15 sampans that survived the strafing by planes. She pushed on for airstrike operations on Peleliu, Palau the Carolines and Luzon, Manila, and Samar Island, Philippines, through September.

On 2 October Morrison sailed with TG 83.3 for picket duty off Okinawa, during the airstrikes there and on other Islands in the Ryukyus 10 October. She continued on screen and plane guard operations off Formosa and northern Luzon during a 5-day attack beginning the 12th. On 16 October she screened Houston (CL-81) and Canberra (CA-70) as they retired to Ulithi.

During the Battle for Leyte Gulf, 23 to 26 October, Morrison operated off Luzon. On the 24th, she came to the aid of Princeton (CVL-23), badly hit by a Japanese bomb, and picked up approximately 400 survivors in an hour and a half. The destroyer then pulled alongside Princeton to assist in fighting fire she had just reached her position when the small aircraft carrier, drifting and rolling, wedged Morrison&rsquos mast and forward stack between her uptakes. Morrison managed to get clear and Birmingham (CL-62) took her place. Ten minutes later the after third of Princeton blew off. Not only, did Birmingham suffer topside damage and heavy casualties, but Princeton was then so badly damaged she had to be sunk by torpedoes.

Morrison debarked the Princeton survivors at Ulithi 27 October and got underway for the west coast, via Pearl Harbor, in company with Irwin (DD-794) and Birmingham, arriving San Francisco, Calif., 17 November. On 9 February the destroyer steamed back to the South Pacific, stopping at Pearl Harbor the 15th.

After shore bombardment exercises in the Hawaiian Islands, Morrison departed for Ulithi 3 March. By 21 March she had joined TF 54 underway for Okinawa out of Ulithi. The destroyer arrived off the southern shores of Okinawa the 25th, 7 days before the landings 1 April, and joined in the preparations of bombardment.

In the early morning of 31 March, after Stockton (DD-646) made a positive sound contact off Okinawa and expended her depth charges in the attack, Morrison arrived on the scene to see the submarine surface, then immediately submerge. She dropped a pattern of charges which seconds later forced the sub to the surface where it was sunk by gunfire. At daylight Morrison&rsquos small boats rescued the lone survivor.

The ship continued shore bombardment, night illumination, and screen operations off Oshima Beach. The night of 11 April Morrison assisted Anthony (DD-515) in illuminating and sinking enemy landing craft heading north along the beach.

Three days later Morrison began radar picket duty. Her first two stations, southwest of Okinawa, were occasionally raided at night. She replaced Daly (DD-519) at the third station 28 April after the other destroyer was hit by a kamikaze.

On 30 April Morrison was shifted to the most critical station on the picket line. After 3 days of bad weather had prevented air raids, the dawn of 4 May was bright, clear, and ominous. At 0715 the combat air patrol was called on to stop a force of about 25 planes headed toward Morrison, but some got through.

The first attack on Morrison, a main target as fighter-director ship, was a suicide run by a &ldquoZeke.&rdquo The plane broke through heavy flack to drop a bomb which splashed off the starboard beam and exploded harmlessly. Next a &ldquoVal&rdquo and another &ldquoZeke&rdquo followed with unsuccessful suicide runs. About 0825 a &ldquoZeke&rdquo approached through intense antiaircraft fire to crash into a stack and the bridge. The blow inflicted heavy casualties and knocked out most of the electrical equipment. The next three planes, all old twin-float biplanes, maneuvered, despite heavy attack, to crash into the damaged ship. With the fourth hit, Morrison, heavily damaged, began to list sharply to starboard.

Few communication circuits remained intact enough to transmit the abandon ship order. Two explosions occurred almost simultaneously, the bow lifted into the air, and by 0840 Morrison had plunged beneath the surface. The ship sank so quickly that most men below decks were lost, a total of 152.

In July 1957 the sunken hull of Morrison was donated, along with those of some 26 other ships sunk in the Ryukyus area to the Government of the Ryukyu Islands for salvage.

Driver in fatal crash has long history of DUI arrests

STOCKTON —ਊ 42-year-old Lathrop man suspected of driving drunk when he crashed his sports utility vehicle into a tree Friday, killing his 12-year-old daughter who was a passenger, has faced DUI charges about a half a dozen times before, court records show.

Joe Victor Zigler, who is likely to face criminal charges after he is allowed to leave a hospital, has a court history that spans 12 total cases since 2003. And while some are alcohol related, others stem from elder abuse.

Joe Zigler had recently completed an alcohol treatment program for a 2010 drunk-driving conviction when the crash that claimed Jo-Kisea Zigler’s young life happened on California Street, south of East Ninth Street.

On Jan. 6, 2010, Zigler pleaded guilty to a felony count of driving under the influence with a blood alcohol level of .08 or higher and enhancements for having three or more prior convictions.

At the time, San Joaquin County Superior Court Judge Bernard Garber sentenced him to two years in state prison and imposed a $2,397 penalty.

Court records say Zigler was driving at the time with a blood alcohol level more than twice the legal limit.

Zigler also was convicted on a separate case during the same hearing, when he pleaded guilty to battery for a July 19, 2009, violation.

The priors noted in Zigler’s 2010 conviction:

On April 18, 2008, he pleaded guilty to driving under the influence with a blood alcohol level of .08 percent or higher and admitted to an enhancement for having three priors. He was sentenced to 16 months of incarceration.
On May 14, 2007, he pleaded guilty to one felony count of driving under the influence with a blood alcohol level of .08 percent or higher on June 6, 2006, and admitted to an enhancement for having three priors. He also had been driving with a suspended license for driving drunk, prosecutors alleged in that incident, but that charge was dismissed.
On May 10, 2005, he pleaded no contest to driving under the influence with a blood alcohol level of .08 percent or higher on March 20, 2005, and admitted to an enhancement for having three priors, and to driving with a suspended license for driving drunk.

But before those cases arose, Zigler had been arrested in September 2004 on an incident from July 2003. In that case, he pleaded guilty to driving under the influence with a blood alcohol level of .08 percent or higher and admitted to having one prior DUI.

Zigler’s court records seem to paint a violent picture.

When Zigler faced drunk-driving charges in May 2005, prosecutors also sought him in a separate case for having committed elder abuse. He pleaded guilty to misdemeanor elder or adult dependent cruelty in an April 29, 2005, occurrence.

Prior to that, Zigler pleaded no contest to false imprisonment by violence on July 21, 2004, for an incident on April, 19, 2004. Three counts of false imprisonment and two counts of battery were dismissed.

And more recently, in 2012, Zigler again was taken into custody on suspicion of assaulting an elderly person. He pleaded guilty to causing harm on an elder or adult dependent and an enhancement for having a prior prison term. In the resolution, authorities dismissed charges of assault with force likely to cause great bodily injury and making criminal threats with enhancements attached to the charges.

Most of his priors were violations out of Manteca.

Now Zigler, who is being guarded by Stockton police officers at an area hospital, is expected to be booked into San Joaquin County Jail once he is medically discharged. He remains in critical condition but is਎xpected to survive, officials said.

According to Stockton police, Zigler was reaching high speeds driving his 2001 Ford Expedition on California Street when he failed to properly negotiate a curve on the road and crashed into a tree south of East Ninth Street around 9:52 p.m. Friday. The impact caused his daughter, a sixth-grader at Mossdale Elementary School in Lathrop, to be ejected from the vehicle and succumb to her injuries. She was not wearing a seatbelt.

The child’s mother, 34-year-old Rocheka Thomas, who is the suspect’s girlfriend, also was in the SUV. She was released from a hospital on Sunday, said Stockton police spokesman Officer Joe Silva.

Authorities said they found evidence that there was alcohol involved, and relatives say the family was heading home after a party in Stockton.

Zigler is expected to be booked on suspicion of driving under the influence resulting in death, but the San Joaquin District Attorney’s Office will decide the charges once it receives investigation reports.

Authorities have not indicated whether Thomas will face criminal charges, too.

Stockton III DD-646 - History

Copyright: 2002-2021, PathologyOutlines.com, Inc.

Generic term for nonneoplastic mixture of epithelial and stromal components admixed with inflammatory cells
Often related to inflammatory bowel disease (Crohn's disease or ulcerative colitis), anastomosis, ischemic colitis or infection

Nonneoplastic colon polyp composed of inflamed mucosa
Typically shows surface erosion with surrounding granulation tissue and epithelial distortion

Inflammatory polyp as a diagnosis is generally used to describe small foci of nonspecifically inflamed colonic mucosa or inflammatory pseudopolyps

Inflammatory polyp as a category includes several subtypes, including:

Inflammatory cap polyp
Inflammatory fibroid polyp
Inflammatory myoglandular polyp
Prolapse associated polyps

Typically second and third decades for inflammatory bowel disease incidence range of 10 - 20% in ulcerative colitis patients (World J Gastroenterol 201723:1541)
May occur in older patients with peripheral vascular disease

Can arise anywhere in the colon, especially at the ileocecal region in Crohn’s disease
May form at anastomotic sites

Believed to be secondary to repeated bouts of intense inflammation
Formation of inflammatory polyps may be related to increases in C reactive protein, C4 and procollagen III peptide (World J Gastroenterol 20039:619)

Sporadic inflammatory polyps are usually incidental at colonoscopy
May present with intussusception or obstructive symptoms

Presence of pseudopolyps in inflammatory bowel disease may represent recent flare, although lesions are found in active or dormant disease (World J Gastroenterol 201723:1541)

Also may be related to arthropathy or other extracolonic symptoms (Lancet 19692:555)

28 year old woman with pseudosarcomatous changes in inflammatory polyp (Korean J Gastrointest Endosc 200735:51)
47 year old man with intussusception due to 3 cm inflammatory polyp (Asian J Surg 200528:58)
62 year old man with inflammatory polyp due to Kirschner wire (Intern Med 201453:699)
74 year old man with inflammatory polyp with osseous metaplasia (Gastroenterology Res 20125:74)
Patient with inflammatory polyp containing schistosomiasis (bilharzial polyp) (J Clin Gastroenterol 19835:169)

Typically treated endoscopically via polypectomy
Examples related to inflammatory bowel disease may improve with infliximab (J Crohns Colitis 20104:707)
Argon plasma coagulation or ablation for bleeding control
Surgical resection if profuse bleeding, obstruction or intussusception

Inflammatory pseudopolyps in ulcerative colitis

Often consists of normal colonic mucosa in a polypoid configuration, with increased inflammation (expanded lamina propria and crypt abscesses or cryptitis)
Epithelium can show various degrees of surface erosion, crypt distortion / dilation or hyperplasia, along with reactive nuclear features within the mucosal epithelial cells
May consist entirely of granulation tissue (abundant thin walled and dilated vessels surrounded by mixed neutrophilic and lymphoplasmacytic inflammation)
Reactive stromal cells may be markedly pleomorphic and mimic sarcoma
Cases associated with inflammatory bowel disease may rarely show epithelial dysplasia

Dense inflammation in lamina propria

Surface mucosal ulceration

Surface erosion with granulation tissue

Inflammatory polyp on colonoscopy

Large cystically dilated glands wide histologic overlap and the distinction is of little importance in adult patients

Lobular arrangement of capillaries within edematous stroma (Ann Diagn Pathol 20059:106)

Which of the following is not a typical feature of colonic inflammatory polyps?

Crypt distortion / branching
Granulation tissue changes
Microsatellite instability
Surface mucosal erosion

C. Microsatellite instability. Inflammatory polyps are a benign process with various degrees of mucosal erosion, increased vascular density similar to granulation tissue and architectural changes.

Office History

The first convening of the District Court of New Jersey was held on December 22, 1789, at which time three attorneys were sworn in and Richard Stockton, then 25 years old, was commissioned as the first United States Attorney for the District of New Jersey.

Richard Stockton (1764-1828) by Christian Gullager

Stockton, nicknamed "the Duke," had come from a prominent family in New Jersey. His great-grandfather (also named Richard Stockton) purchased the property that became Morven (later the residence of several New Jersey governors) from William Penn in 1701. His father, perhaps the most famous Richard Stockton, signed the Declaration of Independence a little more than a decade before "the Duke" became the first "attorney of the district." Stockton spent most of his time dealing with cases arising from the maritime trade from nearby ports. These cases involved the collection of customs duties on goods brought through the New Jersey ports from foreign countries. When Stockton left office in 1791, he was widely considered the best attorney in the state of New Jersey. He became United States Senator for New Jersey in 1796, and he was elected to the United States House of Representatives in 1813.

Like Stockton, many United States Attorneys held significant posts in government before and after their tenure as United States Attorneys. William Sanford Pennington left the United States Attorney's Office in 1804 to become an Associate Justice of the New Jersey Supreme Court, and in 1813 he became the governor of New Jersey. (His son, William Pennington, would later be the governor of New Jersey from 1837 to 1843.) From 1815 until his death in 1826, Pennington served as the United States District Judge for the District of New Jersey. (Until 1905, the District of New Jersey was served by only a single district judge.) Pennington had become well known for his courage during the Revolutionary War, when General Knox once spotted him under enemy fire loading and firing a cannon by himself, a task usually requiring the work of two or three people. The town of Pennington, New Jersey, is named for him.

Frederick Frelinghuysen became United States Attorney in 1801 having already distinguished himself in government service. He had served as a colonel in the Revolutionary War as a delegate to the Continental Congress and as a United States Senator from 1793 to 1796. After he left the Office of United States Attorney, Frelinguysen served as a member of the State general assembly. A number of Frelinghuysen's descendants served in government as well, including his son Theodore (1787-1862) and his grandson Frederick Theodore Frelinghuysen (1817-1885), both of whom became United States Senators. His great-great-great-grandson, Peter Hood Ballantine Frelinghuysen, Jr., was a member of the House of Representatives from 1953 to 1975, and his great-great-great-great grandson, Rodney Frelinghuysen, was elected to the House of Representatives in 1995.

Joseph McIIvaine took office as the United States Attorney in 1804 and served for almost 20 years. Later, from 1823 until his death in 1826, he served in the United States Senate. McIIvaine's successor, Lucius Q.C. Elmer, had quite a career both before and after serving as United States Attorney from 1824 to 1829. Elmer had been a prosecuting attorney for the State and a member of the New Jersey Assembly, becoming Speaker of the House in 1823. He was elected to the United States Congress in 1843. He was not reelected, but he served as New Jersey's Attorney General from 1850 to 1852 and served as an Associate Justice of the New Jersey Supreme Court from 1852 until his retirement in 1869.

The ninth United States Attorney, Garret Dorset Wall, had served in the War of 1812 and then become Quartermaster General for the State of New Jersey. He carried the title of "General" all of his life. As a member of the New Jersey Legislature, in 1829 he was selected by his peers to be governor. He became the only man appointed governor who declined to serve. Instead, he served as United States Attorney from 1829 to 1835. Then, from 1835 to 1841, he served as a United States Senator. Shortly after his death in 1850, Monmouth County's Wall Township was named after him.

On March 27, 1861, Anthony Q. Keasbey began the longest tenure of any United States Attorney in the District he served continuously for 25 years, until 1886. The Keasbey section of Woodbridge Township, New Jersey, was named for Keasbey and his brothers.

David O. Watkins, United States Attorney from 1900 to 1903, had earlier in his career been elected mayor of the City of Woodbury. At the time, he was only 24 years of age. In what may be another first, Watkins served as governor before becoming United States Attorney. In 1898, a set of odd circumstances brought Watkins to the governorship when both the elected governor and the President of the New Jersey Senate resigned while Watkins was Speaker of the House for the New Jersey Assembly. By succession, Watkins became the acting governor two years before becoming United States Attorney.

Other unusual events have occurred in the history of the United States Attorney's Office. The first United States Attorney, Richard Stockton (1789-1791), and the third, Lucius Horatio Stockton (1798-1801), were brothers. In more recent times, another pair of brothers have held the office, Raymond Del Tufo, Jr. (1954) and Robert J. Del Tufo (1977-1980).

Palbociclib and INCMGA00012 in People With Advanced Liposarcoma

Condition or disease	Intervention/treatment	Phase
Well Differentiated Liposarcoma Dedifferentiated Liposarcoma	Drug: INCMGA00012 Drug: Palbociclib	Phase 2

Study Type :	Interventional (Clinical Trial)
Estimated Enrollment :	30 participants
Allocation:	N/A
Intervention Model:	Single Group Assignment
Intervention Model Description:	This is a phase II study of palbociclib plus INCMGA00012 in patients with advanced WD/DD liposarcoma.
Masking:	None (Open Label)
Primary Purpose:	Treatment
Official Title:	A Phase II Study of CDK4/6 Inhibition (Palbociclib) Combined With PD-1 Blockade (INCMGA00012) in Patients With Advanced Well-differentiated and/or Dedifferentiated Liposarcoma
Actual Study Start Date :	June 17, 2020
Estimated Primary Completion Date :	June 2023
Estimated Study Completion Date :	June 2023

Resource links provided by the National Library of Medicine

One treatment cycle will consist of 28 days. Patients in both study phases will start palbociclib on Day 1 and INCMGA00012 on day 15 (+/- 7 days) of each cycle at the following dose schedule:

INCMGA00012: 500 mg IV (flat dose) q28 days Palbociclib: 125 mg PO daily for 21 days, followed by 7 days off, q28 days Palbociclib will be taken on Day 1 of each cycle for 21 consecutive days followed by 7 days off (days 22-28 of each Cycle). INCMGA00012 will be administered on Day 15 of (+/- 7 days) each cycle and repeat every 28 days.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:	18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No

A diagnosis of metastatic or unresectable WD/DD liposarcoma. Unresectable is defined as if the primary tumor a) cannot be safely removed surgically or b) would benefit from systemic therapy prior to a surgical approach

Measurable disease by RECIST 1.1

a. Target lesions must not be chosen from a previously irradiated field unless there has been radiographically and/or pathologically documented tumor progression in that lesion prior to enrollment

Adequate organ and marrow function as defined below (ULN indicates institutional upper limit of normal):

Absolute neutrophil count ≥ 1.5 x 109/L
Hemoglobin ≥ 8.0 g/dL
WBC ≥ 3.0 x 109/L
Platelets ≥ 100 x 109/L
≤ 1.5 X ULN OR Direct bilirubin ≤ ULN for subjects with total bilirubin levels > 1.5 ULN. Except patients with Gilbert's disease (𕟫x ULN)
AST (SGOT) /ALT (SGPT) ≤ 3 x institutional ULN
Creatinine Clearance > 50 mL/min (calculated by Cockcroft-Gault method)

Patients who have not recovered from clinically significant adverse events of prior therapy to ≤ NCI CTCAE v5 Grade 1, except alopecia and stable neuropathy, which must have resolved to Grade ≤ 2 or baseline.
Patients receiving any other investigational agents.
Patients who have received prior treatment with a selective CDK4 inhibitor or an anti-PD-1/PD-L1 agent

Uncontrolled intercurrent illness including, but not limited to, known ongoing or active infection, including uncontrolled HIV, active hepatitis B or C, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmias, psychiatric illness/social situations that would limit compliance with study requirements, clinically significant interstitial lung disease or active noninfectious pneumonitis, or active infection requiring systemic therapy

Patients with a CD4+ count of > 300 and an undetectable viral load who are currently on HAART are eligible for inclusion
Patients with NYHA class III or IV congestive heart failure within 6 months of study treatment will be excluded

History or evidence of symptomatic autoimmune disease in past 2 years prior to enrollment.

a. Replacement therapy (e.g., thyroxine for hypothyroidism, insulin for diabetes or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment for autoimmune disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04438824

Contact: Sandra D'Angelo, MD	646-888-4159	[email protected]
Contact: William Tap, MD	646-888-4163

United States, New York
Memorial Sloan Kettering Cancer Center	Recruiting
New York, New York, United States, 10065
Contact: Sandra D'Angelo, MD 646-888-4159 [email protected]
Contact: William Tap, MD 646-888-4163

Principal Investigator:

Sandra D'Angelo, MD

Memorial Sloan Kettering Cancer Center

9 Things You May Not Know About the Declaration of Independence

1. The Declaration of Independence wasn’t signed on July 4, 1776.
On July 1, 1776, the Second Continental Congress met in Philadelphia, and on the following day 12 of the 13 colonies voted in favor of Richard Henry Lee’s motion for independence. The delegates then spent the next two days debating and revising the language of a statement drafted by Thomas Jefferson. On July 4, Congress officially adopted the Declaration of Independence, and as a result the date is celebrated as Independence Day. Nearly a month would go by, however, before the actual signing of the document took place. First, New York’s delegates didn’t officially give their support until July 9 because their home assembly hadn’t yet authorized them to vote in favor of independence. Next, it took two weeks for the Declaration to be 𠇎ngrossed”—written on parchment in a clear hand. Most of the delegates signed on August 2, but several𠅎lbridge Gerry, Oliver Wolcott, Lewis Morris, Thomas McKean and Matthew Thornton—signed on a later date. (Two others, John Dickinson and Robert R. Livingston, never signed at all.) The signed parchment copy now resides at the National Archives in the Rotunda for the Charters of Freedom, alongside the Constitution and the Bill of Rights.

2. More than one copy of the Declaration of Independence exists.
After the adoption of the Declaration of Independence, the 𠇌ommittee of Five”—Thomas Jefferson, John Adams, Benjamin Franklin, Roger Sherman and Robert R. Livingston—was charged with overseeing the reproduction of the approved text. This was completed at the shop of Philadelphia printer John Dunlap. On July 5, Dunlap’s copies were dispatched across the 13 colonies to newspapers, local officials and the commanders of the Continental troops. These rare documents, known as 𠇍unlap broadsides,” predate the engrossed version signed by the delegates. Of the hundreds thought to have been printed on the night of July 4, only 26 copies survive. Most are held in museum and library collections, but three are privately owned.

3. When news of the Declaration of Independence reached New York City, it started a riot.
By July 9, 1776, a copy of the Declaration of Independence had reached New York City. With hundreds of British naval ships occupying New York Harbor, revolutionary spirit and military tensions were running high. George Washington, commander of the Continental forces in New York, read the document aloud in front of City Hall. A raucous crowd cheered the inspiring words, and later that day tore down a nearby statue of George III. The statue was subsequently melted down and shaped into more than 42,000 musket balls for the fledgling American army.

4. Eight of the 56 signers of the Declaration of Independence were born in the U.K.
While the majority of the members of the Second Continental Congress were native-born Americans, eight of the men voting for independence from Britain were born in the United Kingdom. Button Gwinnett and Robert Morris were born in England, Francis Lewis was born in Wales, James Wilson and John Witherspoon were born in Scotland, George Taylor and Matthew Thornton were born in Ireland and James Smith hailed from Northern Ireland.

5. One signer of the Declaration of Independence later recanted.
Richard Stockton, a lawyer from Princeton, New Jersey, became the only signer of the Declaration of Independence to recant his support of the revolution. On November 30, 1776, the hapless delegate was captured by the British and thrown in jail. After months of harsh treatment and meager rations, Stockton repudiated his signature on the Declaration of Independence and swore his allegiance to King George III. A broken man when he regained his freedom, he took a new oath of loyalty to the state of New Jersey in December 1777.

6. There was a 44-year age difference between the youngest and oldest signers.
The oldest signer was Benjamin Franklin, 70 years old when he scrawled his name on the parchment. The youngest was Edward Rutledge, a lawyer from South Carolina who was only 26 at the time. Rutledge narrowly beat out fellow South Carolinian Thomas Lynch Jr., just four months his senior, for the title.

7. Two additional copies of the Declaration of Independence have been found in the last 25 years.
In 1989, a Philadelphia man found an original Dunlap Broadside hidden in the back of a picture frame he bought at a flea market for $4. One of the few surviving copies from the official first printing of the Declaration, it was in excellent condition and sold for $8.1 million in 2000. A 26th known Dunlap broadside emerged at the British National Archives in 2009, hidden for centuries in a box of papers captured from American colonists during the Revolutionary War. One of three Dunlap broadsides at the National Archives, the copy remains there to this day.

8. The Declaration of Independence spent World War II in Fort Knox.
On December 23, 1941, just over two weeks after the Japanese attack on Pearl Harbor, the signed Declaration, together with the Constitution, was removed from public display and prepared for evacuation out of Washington, D.C. Under the supervision of armed guards, the founding document was packed in a specially designed container, latched with padlocks, sealed with lead and placed in a larger box. All told, 150 pounds of protective gear surrounded the parchment. On December 26 and 27, accompanied by Secret Service agents, it traveled by train to Louisville, Kentucky, where a cavalry troop of the 13th Armored Division escorted it to Fort Knox. The Declaration was returned to Washington, D.C., in 1944.

9. There is something written on the back of the Declaration of Independence.
In the movie National Treasure, Nicholas Cage’s character claims that the back of the Declaration contains a treasure map with encrypted instructions from the founding fathers, written in invisible ink. Unfortunately, this is not the case. There is, however, a simpler message, written upside-down across the bottom of the signed document: “Original Declaration of Independence dated 4th July 1776.” No one knows who exactly wrote this or when, but during the Revolutionary War years the parchment was frequently rolled up for transport. It’s thought that the text was added as a label.

Pacific football great LeBaron dies at 85

Edward &ldquoEddie&rdquo LeBaron Jr., the "Little General," passed away early this morning of natural causes at the age of 85 in Stockton.

LeBaron's small stature in no way measured his talent on and off the football field. The native Californian was perhaps the greatest football player in Pacific history. LeBaron was the Tigers' quarterback during its undefeated season in 1949. He was the first quarterback in Dallas Cowboys' history in 1960. LeBaron also played for the Washington Redskins and was selected to the Pro Bowl four times.

LeBaron was an NFL executive with the Atlanta Falcons and was named the league's Executive of the Year in 1980.

LeBaron served as a United States Marine Corps lieutenant and spent nine months in Korea in areas where some of the most fierce fighting took place. He was wounded twice and was awarded a Purple Heart and the Bronze Star for his heroism.

LeBaron obtained a law degree in 1959 from George Washington University and had a successful career as an attorney, practicing in Texas, Nevada and Georgia. LeBaron also developed real estate, including the LeBaron Estates subdivision off Davis Road in Stockton.

LeBaron and his wife, Doralee, also a Pacific alumnus, had three sons: Edward &ldquoWayne&rdquo III, Richard, and William, plus five grandchildren and two great-grandchildren.